SEER Training Modules

Biopsy Example

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Name: Sammy Kidd
Hospital No.: 0000037

Sex: Male
Age: 56
Race: White
Clinical Diagnosis: Carcinoma of Bladder

Address: _______________________________
Path No.: S91-1017

Clinic or Floor:___________________________
Surgery Date: 03/31/91

Pathologic Diagnosis: Papillary transitional cell carcinoma, GR III

Operation: Multiple biopsies of bladder

Attending Physician: O.P. Bixby, MD


The specimen is submitted in formalin in two parts.

Part one is labeled "random bladder biopsy" and consists of two fragments of tissue each measuring approximately 1 x 1 mm.

Part two is labeled "right anterior bladder wall" and consists of multiple fragments of tissue measuring from 1 x 0.5 x 0.5 cm to 2 x 1 x 0.5 cm. This tissue is dark and appears to have hyperplastic epithelium and underlying muscularity.


Sections of random bladder biopsies show mild to moderate epithelial atypia. Sections of urinary bladder labeled "right anterior bladder wall" show a papillary neoplasm with markedly atypical cells and high mitotic activity invading in solid nests into the lamina propria, but not the muscularis. Adjacent mucosa shows severe atypia.


Urinary bladder (biopsy) - Papillary transitional cell carcinoma, Grade III.
Urinary bladder (random biopsies) - Mild to moderate epithelial atypia.

Ralph Abitt, MD