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Survival Rates
Introduction to Leukemia | Types of Leukemia |Risk Factors | Signs & Symptoms | Survival Rates | Unit Review & Quiz

Leukemia

Poor prognostic factors by cell type for leukemia include:

Acute myelogenous leukemia

Age--patients over age 60
WBC > 30,000 per microliter
Serum LDH over 400 IU
Slow response to therapy
Systemic infection at time of diagnosis
Central nervous system involvement
Myeloblastic leukemia other than with cytogenetic abnormality
    in t(8;121)
Myelomonocytic leukemia with abnormal marrow eosinophils

Acute lymphocytic leukemia

Age--younger than 3 or older than 7
Gender--males have worse prognosis
WBC greater than 50,000 per microliter in children or 30,000 per    microliter in adults
Adult form of lymphocytic leukemia
Burkitt type cell leukemia
Any lymphocytic leukemia with immunologic subtype of B cell,
   T cell or null cell
Hepatosplenomegaly, lymphadenopathy, mediastinal mass, central    nervous system involvement
Presence of Philadelphia chromosome abnormality

Response rates for induction therapy

AML        65%
ALL         60 - 80%

Median survival for chronic lymphocytic leukemia by Rai Stage

Stage 0          12 years
Stage I            8 years
Stage II           6 years
Stage III        > 1 year
Stage IV        > 1 year

Myelofibrosis

Median survival is about 5 years.

Myelodysplastic Syndromes (median survival)

Refractory anemia 2-5 years
Refractory anemia with sideroblasts insufficient data
Refractory anemia with excess blasts 6-9 months
Refractory anemia with excess blasts in
   transformation < 6 months
Chronic myelomonocytic leukemia 14-18 months

Essential Thrombocythemia

Median survival is 10-15 years if complications are controlled.