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| Rappaport
and Lukes-Collins Classification | Rye
Classification | Kiel
Classification | | REAL Classification | WHO Classification | |
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| Rappaport
and Lukes-Collins Classification | Rye
Classification | Kiel
Classification | | REAL Classification | WHO Classification | |
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The Working Formulation was developed by the National Cancer Institute in 1982 as a method of translating among the recognized classification systems for non-Hodgkin lymphoma (Rappaport, Dorfman, Lukes and Collins, Kiel, and the British Lymphoma system). The major groups are identified by letters, A - J, and grouped according to prognosis:
| most favorable | Low Grade | A, B, C |
| Intermediate Grade | D, E, F, G | |
| least favorable | High Grade | H, I, J |
| Low Grade | Intermediate Grade | High Grade |
| Small lymphocytic | Follicular large cell | Large cell immunoblastic |
| Follicular small-cleaved cell | Diffuse small cleaved cell | Lymphoblastic |
| Follicular mixed small-cleaved and large cell | Diffuse mixed small and large cell | Small non-cleaved cell (Burkitt and non-Burkitt type) |
| Diffuse large cell |
Cell types categorized as unclassified by the Working Formulation include the non-specific terms malignant lymphoma, non-Hodgkin lymphoma, diffuse malignant lymphoma, nodular or follicular malignant lymphoma, and cutaneous lymphoma.
Differences in histology refer to differences in the first 3 digits of the ICD-O morphology code.
A simultaneous diagnosis of malignant lymphocytic lymphoma (small cell type) and chronic lymphocytic leukemia (CLL) is coded to CLL.
