REAL Classification

The Revised European American Lymphoma Classification (REAL)

I. Precursor B-cell neoplasm:

Precursor B-lymphoblastic leukemia/lymphoma

II. Mature (peripheral) B-cell neoplasms

B-cell chronic lymphocytic leukemia / small lymphocytic lymphoma
B-cell prolymphocytic leukemia
Lymphoplasmacytic lymphoma
Splenic marginal zone B-cell lymphoma (+/- villous lymphocytes)
Hairy cell leuekmia
Plasma cell myeloma/plasmacytoma
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type
Nodal marginal zone lymphoma (+/- monocytoid B-cells)
Follicle center lymphoma, follicular,
Mantle cell lymphoma
Diffuse large cell B-cell lymphoma

Mediastinal large B-cell lymphoma

Primary effusion lymphoma

Burkitt's lymphoma/Burkitt's cell leukemia

T-Cell and Natural Killer Cell Neoplasms

I. Precursor T cell neoplasm:

Precursor T-lymphoblastic lymphoma/leukemia

II. Mature (peripheral) T cell and NK-cell neoplasms

T cell prolymphocytic leukemia
T-cell granular lymphocytic leukemia
Aggressive NK-Cell leukemia
Adult T cell lymphoma/leukemia (HTLV1+)
Extranodal NK/T-cell lymphoma, nasal type
Enteropathy-type T-cell lymphoma
Hepatosplenic gamma-delta T-cell lymphoma
Subcutaneous panniculitis -like T-cell lymphoma
Mycosis fungoides/Sézary's syndrome
Anaplastic large cell lymphoma, T/null cell, primary cutaneous type
Peripheral T cell lymphoma, not otherwise characterized
Angioimmunoblastic T cell lymphoma
Anaplastic large cell lymphoma, T/null cell, primary systemic type

Hodgkin lymphoma (Hodgkin Lymphoma)

Nodular lymphocyte predominance Hodgkin's lymphoma
Classical Hodgkin's lymphoma

•Nodular sclerosis Hodgkin's lymphoma
•Lymphocyte-rich classical Hodgkin's lymphoma
•Mixed cellularity Hodgkin's lymphoma
•Lymphocyte depletion Hodgkin's lymphoma

In addition, multiple subcategories are offered for several of these diseases.