Bone Marrow Studies
Examination of the bone marrow is critically important in the diagnosis and management of a wide variety of hematologic disorders, for example, leukemia. Circulating blood cells are actively produced in the bone marrow. Bone marrow can be obtained by needle aspiration (considered as "positive histology" in the diagnostic confirmation field), by biopsy of tissue utilizing one of a variety of special needles, or by open surgical biopsy with a trephine (histologic examination). An abnormal cytologic examination will generally be supplemented by a histologic examination.
Bone marrow biopsies are discussed in Histologic Examination section.