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FAB Classification of Refractory Anemias

9980/3 Refractory anemia, NOS (20-30% of patients)

Definition

Presence of megaloblastoid erythroid hyperplasia in marrow and macrocytic anemia with reticulocytopenia in blood

ICD-9 code

284.9

Synonyms

  • Refractory anemia with multilineage dysplasia
  • Refractory anemia without sideroblast
  • RA

9982/3 Refractory anemia with sideroblasts (2-5%)

Definition

Same as RA, but with at least 15% of marrow red cell precursors being ringed sideroblasts (characteristic ring-shaped deposits of iron in red blood cell)

ICD-9 code

285.0

Synonym

  • Refractory anemia with ringed sideroblasts
  • RARS

9983/3 Refractory anemia with excess blasts (40%)

Definition

5-20% of marrow is myeloid blasts, 1-5% in circulating blood

ICD-9 code

285.0

Synonyms

  • RAEB

9984/3 Refractory anemia with excess blasts in transformation (25%)

Definition

20-30% of marrow cells are blasts and > 5% blasts in circulating blood; most progress to acute leukemia

ICD-9 code

285.0

Synonyms

  • RAEB-T

9945/3 Chronic myelomonocytic leukemia (15-20%)

Definition

Increased monocytes in blood; marrow may or may not contain increased number of blasts

ICD-9 code

205.1

Synonyms

  • CMML
  • CMMoL

9945/3 Chronic myelomonocytic leukemia in transformation

Definition

Increased biologic activity indicating that chronic leukemia is evolving into acute leukemia

ICD-9 code

205.1

9895/3 Acute myeloid leukemia arising from myelodysplastic syndrome

Definition

A new ICD-0-3 category identifying cases of acute myeloid leukemia that had a preexisting myelodysplastic syndrome

ICD-9 code

205.0

Synonyms

Secondary acute myeloid leukemia

Non-reportable conditions

Pancytopenia

Low levels of all types of blood cells Aplastic anemia complete failure of production of all types of blood cells, as from high doses of chemotherapy or radiotherapy

Fanconi Anemia

Rare familial disorder with symptoms of severe aplastic anemia, hypoplasia of bone marrow and other symptoms

Myelofibrosis, NOS

Filling of the bone marrow with fibrous tissue (SNOMED code)

Secondary

For example, secondary polycythemia, secondary myelofibrosis: conditions resulting from another disease (post-polycythemic myeloid metaplasia, postpolycythernic splenomegaly)