Drugs Commonly Used for Treating Ovarian Cancer
Chemotherapy for epithelial tumors
- Melphalan (alone as primary adjuvant treatment)
- Ifosfamide (for recurrence)
- Hexamethylmelamine (for recurrence)
- CAP (cytoxan, adriamycin, cisplatin)
- CP (cytoxan and cisplatin)
- CC (cytoxan and carboplatin)
- H-CAP or CHAD (hexamethylmelamine, cytoxan, adriamycin, cisplatin)
- AP (adriamycin and cisplatin)
- HEXA-CAF (hexamethylmelamine, cytoxan, methotrexate, 5-FU)
Chemotherapy for germ cell tumors
- VAC (vincristine, dactinomycin, cytoxan)
- BEP (cisplatin, etoposide, bleomycin)
- BVP (cisplatin, vinblastine and bleomycin)
- VPP (etoposide and cisplatin)
Tamoxifen (for recurrence)
Biological Response Modifiers
Autologous bone marrow transplant is under clinical evaluation as an adjunct to high dose chemotherapy.
Radiation therapy for epithelial ovarian cancers is reserved for treatment of metastases.
For germ cell tumors, prophylactic irradiation to the mediastinal and supraclavicular lymph nodes may be considered. Radioactive phosphorus (P32) can control ascites but causes adhesions and bowel complications.