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SEER Training Modules

Other Therapies

Radiation Therapy

Adjuvant intracavitary or whole pelvic radiation therapy is recommended when the endometrial tumor is grade 3 or the tumor invades more than half the depth of the myometrium. For stage II or greater disease, preoperative intracavitary radiation and postoperative external beam radiation should be considered.

Radioactive phosphorus (P32) may be used for intraperitoneal treatment of metastases.

Drugs Commonly Used for Treating Endometrial Cancer

No standard chemotherapy regimen, although adriamycin and cisplatin have been tried in various combinations

Drugs Commonly Used for Treating Placental Cancer

  • Methotrexate alone
  • Methotrexate with leukovorin rescue
  • Actinomycin D
  • Combinations
  • MAC (methotrexate, actinomycin D, cytoxan or chlorambucil)
  • EMA-CO (etoposide, methotrexate, actinomycin D, vincristine, cytoxan)
  • EMA-CE (etoposide, methotrexate, actinomycin D, etoposide, cisplatin)

Hormones for Endometrial Cancers

(for extensive disease or recurrence)

  • Medroxyprogesterone acetate (Depo-Provera)
  • Hydroxyprogesterone (Delalutin)
  • Megestrol acetate (Megace)
  • Tamoxifen

Biological Response Modifiers

Under clinical evaluation.