Commonly Used Drugs


Chemotherapy is recommended as adjuvant for Stage III disease (positive lymph nodes)

  • 5-FU alone
  • 5-FU and levamisole (Biological Response Modifier)
  • 5-FU and leucovorin (under clinical evaluation)-ancillary drug
  • 5-FU plus radiation therapy for rectal cancer
  • Portal vein infusion of 5-FU for known or suspected liver metastases (under clinical evaluation—has shown improvement in palliation but not in survival)


MOF—5-FU, Methyl-CCNU and vincristine (no longer considered to be appropriate adjuvant treatment per NCI because of M-CCNU's renal toxicity and leukemogenic effect)


Not useful for colorectal cancer

Biological Response Modifiers

Under clinical evaluation