Rye Classification for Hodgkin Disease
Developed by Lukes and Butler; modified and presented at a conference in Rye, New York in 1966. This system found that the different cellular subtypes had different prognoses:
|Most favorable||Lymphocyte predominant||96513 (NOS), 96583 (diffuse), 96513 (nodular)|
|Favorable||Nodular sclerosis||96633 (NOS), 96643 (cellular phase) also: 96653 (HD NS, lymphocyte predominance) 96653 (HD NS mixed cellularity), 96673 (HD NS, lymphocytic depletion)|
|Guarded||Mixed cellularity||96523 (NOS)|
|Least favorable||Lymphocyte depletion||96533 (NOS) 96543 (diffuse fibrosis), 96553 (reticular)|
Reed-Sternberg cells are diagnostic of Hodgkin's disease because of their specific morphologic characteristics.