SEER Training Modules
Rye Classification for Hodgkin Disease
Developed by Lukes and Butler; modified and presented at a conference in Rye, New York in 1966. This system found that the different cellular subtypes had different prognoses:
| Prognosis | Classification | Histologic Features |
|---|---|---|
| Most favorable | Lymphocyte predominant | 96513 (NOS), 96583 (diffuse), 96513 (nodular) |
| Favorable | Nodular sclerosis | 96633 (NOS), 96643 (cellular phase) also: 96653 (HD NS, lymphocyte predominance) 96653 (HD NS mixed cellularity), 96673 (HD NS, lymphocytic depletion) |
| Guarded | Mixed cellularity | 96523 (NOS) |
| Least favorable | Lymphocyte depletion | 96533 (NOS) 96543 (diffuse fibrosis), 96553 (reticular) |
Reed-Sternberg cells are diagnostic of Hodgkin's disease because of their specific morphologic characteristics.
