EOD Primary Tumor

For invasive bladder tumors, extent of the tumor is based on how far the tumor has gone through the bladder wall.

Non-invasive/in situ (/2)

  1. Non-invasive urothelial carcinoma
  2. In-situ non-urothelial carcinoma

Invasive (/3)

  1. Invasion of the bladder wall
  2. Muscle invasion
    1. Superficial muscle invasion is defined as less than half-way through the muscle coat (three layers).
    2. Deep muscle invasion is considered half-way or more through the muscle coat.
    3. Note: Superficial or deep muscle invasion can only be measured when a cystectomy has been done. Only muscle invasion (muscularis propria), NOS can be determined with a TURB.
  3. Invasion of perivesical fat
    1. Perivesical fat is a layer of fat surrounding the bladder outside of the adventitia/serosa
  4. Extravesical tumor with extension to adjacent structures
    1. Extravesical means outside of the bladder (intravesical means within the bladder)
    2. Adjacent structures include prostate, prostatic urethra, urethra, ureter, uterus, vagina, large intestine, rectum, small intestine, bone, pelvic wall, pubic bone

Note: There is a high degree of correlation between the grading (differentiation or aggressiveness) of the tumor and the stage (invasiveness).

See SEER*RSA, Bladder, for the current version of EOD and complete coding instructions for the Bladder schema.

Updated: April 22, 2025