Morphology & Grade

ICD-O Morphology Codes

If the diagnostic term in the pathology report is not in the list below, be sure to consult your ICD-O manual.


  • Adenocarcinoma (81403)
    • Mucinous (colloid) carcinoma (84803)
  • Duct cell carcinoma (85003; 90% of all cases)
  • Islet cell carcinoma (81503; NOS arise in Islets of Langerhans)
  • Insulinoma (81513; produce insulin)
  • Glucagonoma (81523; produce glucagon)
  • Gastrinoma (81533; produce gastrin)

Other histologies

  • Wilms tumor (nephroblastoma; 89603)—large bulky tumor of childhood; rare in adults
  • Lymphoma (many cell types)
  • Sarcoma (many cell types)
  • Hemangiopericytoma (91503)
  • Cystadenocarcinoma (84403; arise in tail of pancreas)
  • Other cell types: papillary cystic carcinoma (84521); adenoacanthoma (85703);
  • pancreatoblastoma (89713) and many others
  • Mixed islet cell and exocrine adenocarcinoma (81543)
  • Lymphomas and sarcomas (many cell types)

Key words

  • Apudoma (82481)
  • Vipoma tumor producing vasointestinal peptide


  • Adenocarcinoma (81403)
    • Subtypes: signet ring cell, clear cell, colloid, oat cell and others


  • Hepatoma (81703; 70-90 % of all primary liver tumors; also called hepatocellular, hepatocarcinoma, or liver cell carcinoma)
  • Fibrolamellar hepatocellular carcinoma (81713)
  • Combined hepatocellular carcinoma and cholangiocarcinoma (81803)

Ampulla of Vater

  • Adenocarcinoma (81403)

Bile Ducts (intra and extrahepatic)

  • Cholangiocarcinoma (81603; also called bile duct carcinoma) Klatskin's tumor (81623) Adenocarcinoma (81403; most common for extrahepatic bile duct tumors) Sarcomas (several types)

Synonyms for in situ carcinoma: (adeno)carcinoma in an adenomatous polyp with no invasion of stalk, confined to epithelium, noninfiltrating, intraepithelial, involvement up to but not including the basement membrane, noninvasive, no stromal involvement, papillary noninfiltrating.