Commonly Used Drugs

Chemotherapy

• Chemotherapeutic agents have, to date, not been too successful as adjuvants to surgical or radiotherapeutic treatment. Partial responses have been noted with single agent methotrexate, adriamycin, 5-FU, cytoxan, mitomycin C and cisplatin.
• Intravesical chemotherapy has been shown to reduce recurrences
• Thio-TEPA
• Doxorubicin
• Mitomycin C

Combinations

• M-VAC (methotrexate, vinblastine, doxorubicin, cisplatin)
• MCV (methotrexate, cisplatin, vinblastine) (under clinical evaluation)

Hormones (not useful for treating bladder cancer)

Biological Response Modifiers

• BCG (bacillus Calmette-Guerin)
• Alpha interferon 2B (intravesical)
• Granulocytic colony stimulating factor (G-CSF)