Other Therapies

Systemic Therapy

Under clinical investigation for treatment of various head and neck cancers is Isoretinoin (Retin-A). Used daily for a year, it may prevent development of subsequent primaries.

Key words

Neoadjuvant chemotherapy
Chemotherapy administered prior to surgery or radiation therapy, intended to shrink tumor mass and make it more treatable by another modality.

Chemotherapy agents used alone or in combinations:

  • Cisplatin
  • 5-FU
  • Bleomycin
  • Methotrexate
  • Doxorubicin (adriamycin)
  • Cyclophosphamide

Biological Response Modifiers

Interferon

Suggested Citation

SEER Training Modules: Other Therapies. U.S. National Institutes of Health, National Cancer Institute. Cited 08 January 2026. Available from: https://training.seer.cancer.gov.