Case Example 9 (Multiple Primary, Histology and Primary Site)

Submandibular gland excision: involvement by follicular lymphoma, WHO grades 2-3A w/ focal diffuse areas consistent with diffuse large B-cell lymphoma (see note). Scans show cervical lymphadenopathy, no other areas involved

Involvement Comments
Lymph nodes Cervical
Organ involvement Submandibular gland
Common metastatic sites N/A

Coding of the case (Lymphoma schema)

Data Item Coding
M Rule M4-Code one primary when 2 or more non-Hodgkin lymphomas are in the same lymph node (same location, same biopsy).
See Rule PH11
PH Rule PH11: Code histology to diffuse large B-cell lymphoma when one or more NHL are in the same lymph node and one of the histologies is DLBCL
PH25: Code primary site to the organ when an organ and it’s regional lymph nodes are involved. Cervical lymph nodes are regional for the submandibular gland
Primary site C080 (Submandibular gland)
Histology 9680/3: Diffuse large B-cell lymphoma
Diagnostic confirmation 1 (positive histology)
EOD Primary Tumor 400 (extralymphatic organ and its regional lymph nodes involved)
EOD Regional Nodes 888 (not applicable)
EOD Mets 88 (not applicable)
Summary Stage 2 (extralymphatic organ and its regional lymph nodes involved)
Mets at Dx Data Items (all 6) 0 (no involvement)

Updated: December 2, 2025