Myelodysplastic Syndromes

9989/3 Myelodysplastic Syndromes (MDS)

Defintion

Disruption of production of blood cells—white, red, platelets; development of poor quality blood cells resulting in low levels of mature, functional cells; < 30% blasts in marrow

ICD-9 code

238.7 unless indicated otherwise below

Synonyms

• Pre-leukemia; preleukemic disorders
• Smoldering leukemia; oligoblastic leukemia; subacute myeloid leukemia
• De novo myelodysplastic syndrome - develops with no known cause
• Secondary myelodysplastic syndrome - develops following chemotherapy or radiation therapy for another disease; has poorer prognosis than de novo MDS
• Dysmyelopoietic syndrome; hemopoietic dysplasia