Within the categories of leukemia (ALL, AML, CLL, CML), treatment is similar, but treatment strategies do vary by category. Successful treatment consists of ablation of leukemia in the bone marrow and treatment or prevention of systemic disease, including infiltration of visceral sites.
Administration of treatment in the absence of clinical symptoms to prevent the worsening of the condition; for example prophylactic CNS radiation to prevent CNS involvement, antibiotic prophylaxis to prevent infection
Radiation therapy to the central nervous system is prophylactic treatment to prevent or delay the occurrence of metastases from some varieties of leukemia. CNS radiation is not indicated for AML, but is important for ALL.
Involvement of single lymph node chains with CLL can be treated with radiation therapy.