Risk Factors

Endometrial Cancer

• Use of hormones (estrogens without progesterones)
• Obesity
• Late menopause: after age 52
• Menometrorrhagia: hemorrhagic menses
• Stein-Leventhal syndrome: infertility, anovulatory menses, hirsutism, other endocrine abnormalities
• Family history of multiple cancers
• Personal history of breast cancer or rectal cancer
• Age: less than 5% of cases occur before the age of 40; peak incidence is 70-89 years of age
• Parity: infertility or nulliparity (no childbearing)
• Granulosa cell tumor of the ovary (rare)
• Other chronic conditions (hypertension, diabetes)

Placental Cancer

• Genetic, more common in Asians than Blacks, and least common in Caucasians
• Older women, particularly those older than 40 years
• Multiple pregnancies
• Hydatidiform mole
• Pregnancy
• Abortion
• Ectopic pregnancy
• History of other tumors of the female reproductive tract