Lymphoma

This schema is for a majority of the lymphomas. Lymphomas not included in this schema include Mycosis Fungoides, Primary Cutaneous Lymphomas, Lymphoma Ocular Adnexa, and Lymphoma-CLL/SLL.

Lymphoma staging applies only to the stage group and is based on whether the lymphoma is nodal or extranodal, as well as the overall extent of disease throughout the body.

Data Item Criteria/Comments
Histologies Majority of lymphomas (excluding the schemas and primary sites listed above)
Primary Sites Most of the primary sites (excluding the schemas and primary sites listed above)
EOD Primary Tumor Single nodal or single extranodal organ involved
Two or more nodal regions involved
Single extranodal organ involved with regional lymph nodes
Any of the above with bulky disease
Lymph nodes involved on both sides of the diaphragm with or without spleen involvement, or lymph nodes involved above the diaphragm with spleen involvement
Diffuse, disseminated or multifocal involvement
Peripheral blood involvement only
Metastasis: bone, CNS, bone marrow, CSF, liver, lung
EOD Regional Nodes Not applicable (Code to 888)
EOD Mets Not applicable (Code to 88)
Summary Stage Code 1: Single nodal or extranodal lymphoma
Code 2: Multiple nodal regions involved, extranodal lymphoma with regional lymph node involvement, bulky disease
Code 7: Lymph nodes above and below the diaphragm, diffuse or disseminated involvement, involvement of the bone marrow/peripheral blood, spleen, CSF, liver, lung
B symptoms (SSDI)* These are systemic symptoms of fever, night seats, and weight loss. They are associated with both Hodgkin and non-Hodgkin lymphomas. More common in late stage lymphomas
HIV status (SSDI)* HIV positive patients are at a higher risk of developing lymphomas
NCCN IPI (SSDI)* This is the NCCN International Prognostic Index (IPI). It is for non-Hodgkin lymphomas only. Mostly used with diffuse large B-cell lymphoma (9680/3)
PTLD (SSDI)* This new SSDI introduced in 2025 captures the presence of PTLD when there is a diagnosis of lymphoma, plasmacytoma, and myeloma. See Rules M14 and PH1 in the Hematopoietic manual for more information.

*See the SSDI manual or SEER*RSA for more information on this data item.

Updated: December 2, 2025