The Revised European American Lymphoma Classification (REAL)

I. Precursor B-cell neoplasm:

• Precursor B-lymphoblastic leukemia/lymphoma

II. Mature (peripheral) B-cell neoplasms

• B-cell chronic lymphocytic leukemia / small lymphocytic lymphoma
• B-cell prolymphocytic leukemia
• Lymphoplasmacytic lymphoma
• Splenic marginal zone B-cell lymphoma (+/- villous lymphocytes)
• Hairy cell leuekmia
• Plasma cell myeloma/plasmacytoma
• Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type
• Nodal marginal zone lymphoma (+/- monocytoid B-cells)
• Follicle center lymphoma, follicular,
• Mantle cell lymphoma
• Diffuse large cell B-cell lymphoma
  • Mediastinal large B-cell lymphoma
  • Primary effusion lymphoma
• Burkitt's lymphoma/Burkitt's cell leukemia

T-Cell and Natural Killer Cell Neoplasms

I. Precursor T cell neoplasm:

• Precursor T-lymphoblastic lymphoma/leukemia

II. Mature (peripheral) T cell and NK-cell neoplasms

• T cell prolymphocytic leukemia
• T-cell granular lymphocytic leukemia
• Aggressive NK-Cell leukemia
• Adult T cell lymphoma/leukemia (HTLV1+)
• Extranodal NK/T-cell lymphoma, nasal type
• Enteropathy-type T-cell lymphoma
• Hepatosplenic gamma-delta T-cell lymphoma
• Subcutaneous panniculitis-like T-cell lymphoma
• Mycosis fungoides/Sézary's syndrome
• Anaplastic large cell lymphoma, T/null cell, primary cutaneous type
• Peripheral T cell lymphoma, not otherwise characterized
• Angioimmunoblastic T cell lymphoma
• Anaplastic large cell lymphoma, T/null cell, primary systemic type

Hodgkin lymphoma (Hodgkin Lymphoma)

• Nodular lymphocyte predominance Hodgkin lymphoma
• Classical Hodgkin lymphoma
  • Nodular sclerosis Hodgkin lymphoma
  • Lymphocyte-rich classical Hodgkin lymphoma
  • Mixed cellularity Hodgkin lymphoma
  • Lymphocyte depletion Hodgkin lymphoma

In addition, multiple subcategories are offered for several of these diseases.